You can probably create just about anything you want with the T3 framework. It lends itself to certain layouts more easily than others and the more complex your design, the more you will have to manipulate the template files and not just the back end admin of Joomla. Of course you can create different themes with overrides (such as for different color schemes) and you can even have different layouts per page/component/menu item as well as for each different iteration of things.
If you take a look at our business website in the website design portfolio, you will see mostly custom made templates sone with the T3 framework.
There is definitely a learning curve to this, especially if you don’t already have a great familiarity with css and php, but it is definitely learnable.
Scott Lavelle - Technical Resource Solutions, LLC
Certified Joomla Administrator